Verve Therapeutics said Sunday that the first 10 people to receive a one-time treatment powered by a form of CRISPR called base editing showed reductions in bad cholesterol levels study results that are preliminary but signal the potential for gene-editing treatments to benefit people with an inherited type of cardiovascular disease.
Three of the study participants treated with potentially therapeutic doses of the Verve drug, called VERVE-101, showed reductions in LDL-C levels of 39%, 48%, and 55%, respectively. The latter patient’s decline in so-called bad cholesterol was maintained for six months.
