US President Joe Biden and his Russian counterpart Vladimir Putin are preparing sit down for their first, highly-anticipated summit.
The talks in Geneva, Switzerland, come at a time when both sides describe relations as being at rock bottom.
Issues include arms control, sanctions and US allegations of Russian cyber-attacks and election interference.
No major breakthroughs are expected but there are hopes of finding small areas of agreement.
The summit is set to begin at around 13:00 (11:00 GMT).
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It comes on the tail-end of Mr Biden’s first foreign trip as US president, in which he has also attended meetings with G7 and Nato leaders. Going into the summit, Mr Biden has stressed that he has the backing of his Western partners.
The choice of Geneva as the setting harks back to the Cold War summit between US President Ronald Reagan and Soviet leader Mikhail Gorbachev in 1985.